Cancerous RAGE

Black Rage

If you are attracted to this book by its title you may find it disappointing. It is not about aggression turned outward, about the anger of the blacks, or about the fury which black Americans may vent on the white society they feel oppresses them. Rather, it is a book written by two black psychiatrists about the American Negro's aggression turned inwards?his sense of grief, depression, and self...

RAGE Frameworks

Controlling RAGE

The liver has a finite capacity for regeneration. In mice, removal of 70% of the liver (partial resection) is tolerated but 85% removal (massive resection) is often fatal. Cataldegirmen et al. show on page 473 that blocking RAGE (receptor for advanced glycation end products) allows massively resected mice to survive and regain liver function. Previous studies in mice suggested that recovery aft...

RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases.

Receptor for advanced glycation end-products (RAGE) is known to be involved in microvascular complications in diabetes. RAGE is also profoundly associated with macrovascular complications in diabetes through regulation of atherogenesis, angiogenic response, vascular injury, and inflammatory response. The potential significance of RAGE in the pathogenesis of cardiovascular disease appears not to...

Cardiac RAGE in sepsis: call TOLL free for anti-RAGE.

Sepsis is a systemic inflammatory response syndrome triggered by infection. The hallmarks of clinical sepsis are a broad range of systemic and organ function aberrations, including core temperature (hypothermia or hyperthermia), cardiac (rate and contractility), and respiratory and hematologic perturbations. When sepsis results in at least 1 organ failure or dysfunction, it is classified as sev...